POU domain family values: flexibility, partnerships, and developmental codes.

POU domain family values: flexibility, partnerships, and developmental codes.

POU-domain transcription factors: pou-er-ful developmental regulators.

Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear.

Targeted mutagenesis in mice demonstrates that the POU-domain gene Brn4/Pou3f4 plays a crucial role in the patterning of the mesenchymal compartment of the inner ear. Brn4 is expressed extensively throughout the condensing mesenchyme of the developing inner ear. Mutant animals displayed behavioral anomalies that resulted from functional deficits in both the auditory and vestibular systems, incl...

POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease.

POU domain factors are transcriptional regulators characterized by a highly conserved DNA-binding domain referred to as the POU domain. The structure of the POU domain has been solved, facilitating the understanding of how these proteins bind to DNA and regulate transcription via complex protein-protein interactions. Several members of the POU domain family have been implicated in the control o...

The making of family values: developmental idealism in Gansu, China.

This paper examines the role of developmental thinking in the making of family values. We analyze survey data collected from Gansu Province in China with regular and multilevel logit models. The results show that individuals' endorsement of neolocal residence, self-choice marriage, gender egalitarianism, late marriage for women, and low fertility depends on the conjunction of preference for dev...